Autoclaves and sterilizers are essential devices in a multitude of labs ranging from research, clinical, surgical preparation, and more. Ultra-high heat steam under controlled pressure provides the sterilization conditions required for eradication of pathogens, bacteria, and other contaminants from surfaces and liquids. Configurations include self-contained, portable and benchtop, and integrated systems. Considerations include: the user display and cycle control, venting control and end of cycle alerts, pressure and temperature stability, among others. Attention should be paid to quality of chamber construction and seals important for durable operation.