Mass Spec Matters
As the concept matures, next-generation proteomics promises to usher in a new layer of insight to complement NGS in the realization of true precision medicine. Advanced technologies showcased at the American Society for Mass Spectrometry annual meeting offer progress towards this goal.
Here we highlight a few new HPLC/UHPLC instrument platforms -- those which offer superior flexibility and performance for today’s unique analytical challenges.
Ion Mobility Mass Spectrometry offers a unique layer of separations power and adds yet another dimension for complex, high-throughput applications.
The “smart” laboratory trend has now expanded to include “intelligent” high-end analytical devices – aiming to increase workflow efficiencies and instrument productivity -- while reducing costs and instrument downtime.
These trends may enable more complete biomarker panel validation, greater coverage in complex metabolomics areas such as lipidomics, and ultra high-resolution imaging of complex tissues such as brain.
We detail some of the fundamentals of liquid chromatography and examine emerging trends and new products -- with special focus on nanoflow and chip-based technologies.
The road to biomarker validation is long and arduous, however modern solutions are paving the way for a greater range of entities with untold potential.
With a focus on mass spec methods and solutions, we explore the journey from biomarker discovery, to verification and validation, to clinical implementation.
LabX Industry Insights: Sample Delivery Systems for High Performance Liquid Chromatography and Mass Spectrometry
Programmable high performance syringe pumps are utilized in MS and HPLC applications ranging from method development to instrument calibration
The scandals involving melamine as a food adulterant are valuable case studies as they have led to extensive research into analytical testing.
MS methods for pesticide analysis have evolved over the years as many permutations of extraction, cleanup, separation, and detection have been implemented.
APCI is a soft ionization technique that has proven ideal for fast screening of trace compounds, steroids, pesticides, food adulterants, and other analytes.
In addition to food testing, portable and capable CMS analysis is valuable in industries including water purity, environmental sampling, and diagnostics.
With the growing variety of food sources and products available, there is a requirement for new technologies and testing methods to address safety concerns.