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Unlock Novel Analytical and Purification Strategies for Oligonucleotides

Your Visual Guide to Choosing the Right LC Methods and Columns

The field of oligonucleotide therapeutics is advancing rapidly—and so are the tools used
to analyze and purify these complex molecules. Whether you're working with siRNA,
ASOs, gRNA, or mRNA, understanding which separation chemistry best suits your
needs is crucial to achieving reliable, high-resolution results.
Agilent’s innovative LC and LC/MS column chemistries are designed to streamline oligo analysis—from discovery through scale-up—ensuring optimal resolution, recovery, and throughput.

In this free, easy-to-digest infographic, you’ll find:
 Detailed descriptions of ion-pair reversed-phase, non-ion pair reversed-phase, HILIC, and anion exchange technologies.
 Guidance on choosing analytical, semi-prep, or preparative column formats.
 Tips for selecting MS-compatible workflows with or without desalting.
 A breakdown of oligonucleotide classes and their ideal purification conditions

Who Should Download This Infographic?
 Analytical chemists working with oligonucleotides
 Biopharmaceutical scientists developing or analyzing siRNA, ASO, gRNA, ormRNA
 Method development specialists optimizing LC or LC/MS workflows
 Lab managers overseeing nucleic acid therapeutic analysis and purification
 Anyone transitioning to ion-pair-free or MS-compatible methods

Download the Infographic Now and take the guesswork out of oligonucleotide purification and analysis.

DOWNLOAD THIS INFOGRAPHIC

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