Choosing the Right Microscope: A Practical Buyer’s Guide


A side-by-side guide to match your imaging needs with the right Andor system


Selecting the right microscope requires careful evaluation of your imaging needs, available features, and budget. Whether you are conducting routine lab work or high-end research, understanding the key factors can help ensure you invest in a system that meets your requirements.

This resource provides comprehensive information to help evaluate the features of each Andor microscope. Learn where each system excels—from benchtop convenience to high-end, multi-laser flexibility—with application-first insight provided by Dr. Claudia Florindo.

What you’ll learn

  • Imaging modalities explained: widefield, confocal, SRRF-Stream+ super-resolution, TIRF, and SMLM
  • Laser and detector choices: 4-laser benchtop vs up to 10-laser high-end configurations; sCMOS and EMCCD options
  • Real-world constraints: live vs fixed samples, >500 µm tissue/organoid handling, and fps considerations
  • Budget drivers: how pinholes, dichroics, objectives, stages, and cameras impact your final quote

Who should read this

·       Core facility managers aligning capabilities with diverse user needs

·       PI/lab leads planning near-term experiments and multi-year investments

·       Imaging specialists benchmarking speed, sensitivity, and modality coverage

·       Procurement teams comparing configurations and price drivers with clarity

·       Anyone considering upgrading to new technology

By carefully matching your imaging requirements with instrument capabilities, you can confidently choose the right microscope for your application, ensuring high-quality results and efficiency in your research or diagnostic work.

Download the resource to learn more

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