Explore the principles, process design, and applications of HME in modern drug development
Nearly 90% of new molecules and 40% of marketed
oral drugs face solubility challenges. Hot-melt extrusion (HME) offers a
scalable, solvent-free solution to:
- Enhance
bioavailability of poorly soluble APIs
- Enable
taste masking and abuse deterrence
- Support
controlled and sustained release formulations
- Produce
innovative dosage forms such as implants and films
What You’ll Learn Inside
- Introduction
to HME: principles, benefits, and comparison to spray drying
- Formulation
Characterization: glass transition, melting points, and rheology for
process optimization
- Process
Design & Development: how screw speed, feed rate, temperature
profile, and barrel setup influence product quality
- Downstream
Processing: creating tablets, pellets, oral films, injectable
implants, and 3D-printable filaments
- Case
Studies & Examples: from co-extrusion methods to scale-up
strategies
Who Should Read This Guide
- Pharmaceutical
scientists developing new solid oral and implantable formulations
- Process
engineers optimizing scale-up and manufacturing conditions
- R&D
managers seeking solvent-free, GMP-compliant solutions
- Regulatory
professionals evaluating manufacturing techniques and compliance
