Unlock the Future of Pharmaceutical Manufacturing with Continuous Processing

Explore how hot-melt extrusion (HME) and twin-screw granulation (TSG) are redefining formulation, scale-up, and commercial manufacturing

Pharmaceutical development is shifting dramatically toward continuous, data-driven production. This eBook provides a deep technical review of the science and engineering behind HME and TSG—two complementary, twin-screw–based platforms enabling this transformation.

From fundamental process mechanisms to advanced control strategies, the content walks readers through how these techniques integrate across the continuum from early R&D to commercial production.

What You’ll Learn

1. End-to-End Process Integration: From Molecule to Medicine
2. Hot-Melt Extrusion: Improving Solubility, Release, and Stability
3. Twin-Screw Granulation: Advanced Approaches for Flowability & Uniformity
4. Designing, Optimizing, and Scaling HME Processes
5. Downstream Processing of ASDs: Milling, Tabletability, and Dissolution
6. Real-World Applications & Research Trends

What Makes This eBook a Must-Have Resource

Unlike high-level summaries, this eBook provides mechanistic depth, experimental data, process diagrams, and scale-up models directly applicable to real formulation and manufacturing challenges. Readers will find:

• Residence time distribution curves
• SMEC-based scale-up strategies
• Screw design schematics
• DoE-driven comparisons of downstream milling approaches
• PAT & MPC integration examples
• Detailed case studies grounded in Thermo Fisher Scientific’s Pharma series extruders

This is a practical, engineering-level guide for teams who need to understand not just what HME and TSG can do—but how to these techniques can be implemented successfully in continuous processing workflows.