BMG LABTECH - CLARIOstar Plus

The CLARIOstar^® Plus is our most flexible multi-mode plate reader. It comes equipped with our patented LVF Monochromators™, filters, and spectrometer. Flexibility combined with the best sensitivity of its class, and our newly developed Enhanced Dynamic Range technology, make it the ideal reader for assay development.

CLARIOstar Plus

Detection Modes

Fluorescence intensity (incl. FRET)

Fluorescence polarization

AlphaScreen^®/AlphaLISA^®/AlphaPlex^TM

Luminescence (flash and glow) - incl. BRET

Time-resolved fluorescence

TR-FRET

UV/Vis absorbance spectra

Measurement Modes

Top and bottom reading

Endpoint and kinetic

Sequential multi-excitation

Sequential multi-emission

Spectral scanning (fluorescence, luminescence, absorbance)

Ratiometric measurements

Well scanning

Microplate Formats

6- to 1536-well plates, user-definable

LVis Plate with 16 low volume microspots (2 μL)

Microplate Carrier

Robot compatible

Light Sources

High energy xenon flash lamp

Dedicated laser for AlphaScreen^®/AlphaLISA^®/AlphaPlex^TM

Detectors

Low-noise photomultiplier tube

Red-shifted photomultiplier tube

CCD spectrometer

Wavelength Selection

Dual Linear Variable Filter (LVF) Monochromators™

Linear Variable Dichroic Mirror

Separates ex & em LVF Monochromators

Optical filters:

Ex and em slides hold 4 filters each

LVF Monochromators + optical filters

Use one for ex and the other for em

UV/Vis absorbance spectrometer:

Full spectra or 8 distinct wavelengths in < 1 sec/well

Optical Filters

Excitation and emission slides for 4 filters each

Optical Path Guides

Top and bottom: free-air optical light path guided by motor-driven mirrors and dichroics

Z-Adjustment

Automatic focal height adjustment (0.1 mm resolution)

Spectral Range

Filters

FI, FP, TRF: 240 - 740 nm or 240 - 900 nm (red-shifted PMT)
LUM: 240 - 740 nm
LVF Monochromators™

FI: 320 - 740 nm or 320 - 840 nm (red-shifted PMT)
LUM: 320 - 740 nmLinear Variable Dichroic

340 - 740 nm or 340 - 760 nm (red-shifted PMT)Spectrometer

ABS: 220 - 1000 nm; wavelength precision: ≤ 0.5 nmSensitivity

FI filters < 0.15 pM (< 3 amol/well FITC, 384sv, 20 μL)
(top)

FI filters < 1.0 pM (< 50 amol/well FITC, 384g, 50 μL)
(bottom)

FI monochromator < 0.35 pM (< 7 amol/well FITC, 384sv, 20 μL)
(top)

FI monochromator < 3.0 pM (< 150 amol/well FITC, 384g, 50 μL)
(bottom)

Dynamic Range: 8 decades in a single measurement.

FP < 0.5 mP SD at 1 nM FITC (384sv, 20 μL)

HTRF^®
(black and white microplates)

Reader Control Kit (Eu) after 18h (384sv, 20 μL)
Delta F > 880 % (High Calibrator)
Delta F > 30 % (Low Calibrator)

TRF < 20 fM europium, 384, 80 μL (<1.6 amol/well)

LUM < 0.4 pM (< 8 amol/well ATP, 384sv, 20 μL) Dynamic range: 8 decades in a single measurement

AlphaScreen^®
with laser < 5 pM (< 100 amol/well P-Tyr-100, 384sv, 20 μL)

ABS
with spectrometer

Full spectrum captured in < 1 s / well
Selectable spectral resolution: 1, 2, 5, and 10 nm
OD range: 0 - 4 OD; photometric resolution: 0.001 OD
Accuracy: < 1% at 2 OD
Precision: < 0.5% at 1 OD and < 0.8% at 2 OD

Linearity: ≤ 0.8% at 2.0 OD

Read Times

Flying mode (1 flash) 8 s (96), 15 s (384), 28 s (1536)

19 s (96), 57 s (384), 3 min 4 s (1536)

Reagent Injection

Up to 2 built-in reagent injectors
Individual injection volumes for each well: 3 to 500 µL (optionally up to 2 mL)
Variable injection speed up to 420 µL / s
Reagent back flushing

Shaking

Linear, orbital, and double-orbital with user-definable time and speed

Incubation

+3 °C above ambient up to 45 °C or 65 °C

The upper heating plate of the incubation chamber operates at 0.5 °C more than the lower plate. This prevents condensation build-up on the lid or sealer.

Software

Multi-user reader control (SMART Control and Voyager) and data analysis software (MARS). Voyager is compatible with CLARIOstar Plus readers from serial number 430-4001.

FDA 21 CFR Part 11 compliance available with SMART Control and MARS.

Integrated fluorophore library.

Dimensions

Width: 45 cm, depth: 51 cm, height: 40 cm; weight: 32 kg

Accessories

Atmospheric Control Unit (ACU): provides the ideal environment for cell-based assays by regulating O2 and CO2 gas levels in the microplate reader

Filters and Optic Modules: standard filters from 240 - 850 nm, filters and Optic Modules optimised for specific applications, and bespoke solutions are available

Microplate Stacker: optimises microplate handling and increases throughput by providing rapid loading, unloading, restacking, and continuous feeding for up to 50 microplates

LVis Plate: microplate for low-volume DNA, RNA and protein quantification. It includes 16 micro-drop (2 µL) wells, a cuvette slot and optional performance testing features
Evaluation Plate: validates the optical functionality of BMG LABTECH microplate readers for quality control and/or qualification (IQ/OQ) purposes

Sound Calibrator

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