Thermo Fisher Scientific SurePac Bio 550 SEC MDi

Thermo Fisher Scientific introduces the Thermo Scientific™ SurePac™ Bio 550 SEC MDi™ columns, specifically engineered for the rapid separation of adeno-associated virus (AAV) monomers and aggregates. These columns leverage advanced 3 µm monodisperse particles, ensuring high-resolution separation and optimal retention of AAV monomers.

Key Features:

• Particle Size: The 3 µm monodisperse particles provide enhanced efficiency and resolution, facilitating superior separation of AAV monomers and aggregates.
• MDi Technology: Incorporates inert (MDi) column hardware to maintain consistent particle size distribution. This ensures column-to-column and batch-to-batch reproducibility, crucial for reliable results and robust, easy-to-validate methods.
• Throughput: The smaller particle size allows the use of shorter columns without compromising resolution, enabling faster run times and increased sample processing. This results in significant throughput improvements compared to traditional 5 µm particle technologies.

Applications:

• Gene Therapy and Biopharmaceutical Analysis: Ideal for analytical laboratories requiring precise size exclusion chromatography (SEC) to determine AAV aggregates, critical for cell and gene therapy applications.

Performance:

• High Resolution: The columns provide high-resolution separation, reducing peak broadening effects like eddy-diffusion, which improves the homogeneity of packing.
• Consistency: The use of MDi technology ensures reproducibility, essential for achieving consistent, validated methods in research and production settings.