2022 American Society for Mass Spectrometry (ASMS) conference was held at the
Minneapolis Convention Center June 5th through 9th.
The show had
a great on-site audience and an overall pre-pandemic vibe -- complete
with a rich exhibition floor and the extravagant vendor hospitality suites for
which the meeting is known. Here are a few highlights of new technologies,
solutions, and industry news on display at this year's show.
Shimadzu announced several exciting
new products at ASMS, in addition to the recently released OmegaTOF
8030 Benchtop MALDI-TOF instruments. These announcements include:
The 2050 Single Quadrupole Mass Spectrometer.
This single quad MS (shown right) features reduced size and benchtop
footprint, while maintaining high-speed and performance. The straightforward
design and ease of use make the instrument ideal for use as a LC detector with
advanced MS capabilities.
- The ionization source combines heated
electrospray (HESI) and atmospheric pressure ionization (APCI) as switchable
sources, enabling analysis of a broad range of compounds from multiple chemical
- Ultrafast scan speed (15,000 u/sec) and
polarity switching (10 msec) produces high-quality data at high-throughput
- The 2050 MS is compatible with several LC
and UHPLC separations systems, and easy access to simple methods makes it useful
as an LC detector with significant performance gains over typical PDA
Read More about the Shimadzu LCMS-2050 Single Quadrupole Mass Spectrometer
The iMScope QT Imaging Mass Microscope (shown right) is
designed for use with the Shimadzu Q-TOF LCMS-9030 mass spectrometer for fast
acquisition of high-resolution molecular-level images.
- The instrument platform consists of an
optical microscope and an AP-MALDI ion source, that is coupled upstream of the
Q-TOF LCMS-9030. The system enables identification of molecules in tissue
regions immediately following microscopy analysis.
- Integration with the 9030 Q-TOF enables
high-resolution molecular distribution and quantitative data analysis.
- Microscopy images can be overlaid with MALDI
imaging images to provide comprehensive profiling of tissue morphology and
iMScope QT can also be detached from the MALDI source and coupled to an
ESI-LC-MS system, to provide another level of electrospray accuracy and
- Shimadzu offers a portfolio of solutions and
components to support advanced MS imaging applications, including the iMLayer
matrix sprayer and evaporator system and IMAGEREVEAL image data processing
Shimadzu also announced new LabSolutions MD solutions
software designed to support HPLC method development. With methods scouting
functionality, the software enables automated, quick, and simple column and
solvent screening to provide optimal column separations using the Design of
Experiments (DoE) concept.
Agilent showcased multiple
new developments with the objective to Raise Your Mass Spec iQ.
The 6475 Triple Quadrupole LC-MS/MS (shown right) is
the latest evolution of the 6475 LC-MS/MS workhorse platform. Several advanced technologies benefit this instrument
- Superheated Agilent Jet Stream (AJS) ion
- Curved and tapered collision cell
- Heated and hyperbolic quadrupoles
- +/- 20 kV high-energy dynode detector system
The instrument features new intelligence technologies
such as early maintenance feedback, scheduled tune and check-tune, and
intelligent secondary injection flows. The heighted iQ of the instrument is
designed to perform diagnostics, maintenance, and tuning automatically to maximize
uptime. Reinjections of challenged samples and other featured are meant to let
operators focus on the science rather than performance of the instrument.
Agilent also showcased the new 5977C GC/MSD
instrument (shown right) designed for environmental, food testing, chemical, petrochemical,
forensics, and pharma industry applications.
- Built on the significant legacy of Agilent
GC/MS innovations, the single quadrupole uses the new HydroInert source for
hydrogen carrier applications.
- Designed to address issues with helium
shortages, the HydroInert improves spectral fidelity, peak shape, and
sensitivity when running with hydrogen.
- Built-in intelligence such as remote
monitoring and email-based instrument health alerts make the system easy to
monitor, maintain, and diagnose.
The new 7010C Triple Quadrupole GC/MS is
the most sensitive of the Agilent GC/MS line.
- Designed to tackle applications demanding
the highest sensitivity, the instrument is suited to measure dioxins, furans,
and other trace molecules.
- The high-efficiency ion source (HEIS) can
deliver detection down to the low attogram level.
- Advanced intelligence includes the SWARM
autotune function that operates twice as fast as previous systems.
- New data acquisition modes including
triggered MRM (tMRM) and simultaneous dynamic MRM and scan (dMRM/scan) extend
the instruments performance beyond that of earlier models.
- Method development and migration from the
Agilent 5975 or 5977 GC/MSD is automated and simple using the new MassHunter
Optimizer for the GC Triple Quad.
Agilent also has released the new MassHunter BioConfirm
software which enables routine characterization of biomolecules through easy-to-use
workflows for: oligonucleotides, intact proteins, peptide mapping, and glycan
profiling. The software is part of comprehensive solutions for
biopharma applications in monoclonal antibody and oligonucleotide-based
Bruker showcased several
new releases in the areas of timsTOF proteomics and multiomic tissue imaging
The new timsTOF HT system is
intended to provide extended dynamic range, enhanced peptide coverage, and more
accurate quantitation for unbiased plasma and tissue proteomics analysis.
- The instrument includes the novel 4th
generation TIMS (trapped ion mobility separation) XR cell and a 14-bit digitizer
for enhanced performance and throughput.
- The system can run 50-200 samples per day,
with accuracy better than 1% peptide/protein false discovery rates (FDRs).
- Over 100k unique tryptic peptides in 60min
gradients with accuracy better than 5% CV can be achieved using low microgram
amounts of sample
The new timsTOF Pro 2 system
assists metabolomics and small molecule biomarker studies at unprecedented
- New workflows for biomarker discovery and
small molecule identification are intended to leverage robustness, speed, and
confidence of timsTOF technology in population-level investigations.
- Early studies have shown the system is
capable of non-targeted capture and measurement of 11,000 circulating small
molecule biomarkers, and thousands of yet uncharacterized factors, in human
samples in less than one minute analysis time.
The ability to discover and validate biomarkers at
population-scale in a short amount of time are the features that make the
timsTOF Pro 2 extremely valuable.
Also released at ASMS was the new timsTOF MicroGrid
technology (shown right), for increased resolution of MALDI imaging.
- The technology uses smartbeam 3D MALDI
sources for the timsTOF Flex instruments.
- MicroGrid improves the MALDI stage to
submicron precision and corrects laser positioning on tissue surfaces down to 5
- Importantly, the technology eliminates
visual artifacts or artifact arising from combining MALDI images with optical
images from tissues.
MicroGrid brings new levels of resolution to
molecular pathology applications.
These new products are a mere snapshot of the technology
developments at ASMS. We will continue to explore these new instruments and
solutions in future articles.
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