The recent Vitamin D Day - November 2nd - brings the conversation regarding this essential nutrient to the forefront. What emerging conditions are associated with Vitamin D? How do imbalances correlate with health? What are the best available testing technologies?
With regards to the last question… There are several modern technologies adapted for Vitamin D testing, including those leveraging liquidchromatography coupled to mass spectrometry. The original immunoassay-based Vitamin D tests, developed and commercialized over 25 years ago, however, have long been the standard across the clinical diagnostic landscape.
With the expanding importance of Vitamin D in cardiovascular disease, cancer, diabetes, and other pathologies, the latest immunoassay technologies are proving essential in ensuring accuracy, precision, and throughput for today’s testing needs.
DiaSorin developed the first standardized test back in 1985, the 25-OH Vitamin D radioimmunoassay, which for years was the refence method for the industry. Today the company offers the fully automated LIAISON® 25 OH Vitamin D TOTAL Assay as a testing kit to accurately assess Vitamin D status in patients.
DiaSorin also offers the LIAISON® XL 1,25 Dihydroxyvitamin D chemiluminescent immunoassay for specific quantitation of the bioactive form of the molecule in serum, EDTA, and lithium heparin plasma. This assay kit is designed to run on the LIAISON XL Analyzer.
This latest addition to the LIAISON instrument lineup provides an optimum solution for high-accuracy and high-throughput Vitamin D testing operations.
Siemens offers Vitamin D testing solutions including the Vitamin D Total Assay kit, which is the only CDC certified method that is designed for use with defined pediatric reference values.
Assay specifications are available on the product page.
Biomerieux offers the VIDAS 25 OH Vitamin D Total assay to aid assessment of Vitamin D sufficiency and supplementation follow-up.
The automated assay can be run on the VIDAS family of instruments using ready to use calibrators and controls. Further assay specifications are available on the product page.
Vitamin D testing has never been more important, with growing implications in a host of diseases and metabolic states. Recent peer-reviewed studies have looked at the “Health Effects of Vitamin D Supplementation” and updates of the “Vitamin D Standardization Program (VDSP) intralaboratory study for the assessment of 25-hydroxyvitamin D assay variability and bias”.
Another recent study takes a look at “Vitamin D testing: advantaged and limits of the current assays”, confirming the ongoing evolution and the quest for superior testing technologies and performance.