Opentrons Labworks, Inc. and its subsidiary Neochromosome, Inc. have introduced the Opentrons Flex® neoSwitch™ Workstation, a fully automated platform designed to enhance in-house antibody discovery. By integrating Neochromosome's neoSwitch platform with the Opentrons Flex workstation, laboratories can now automate critical steps in the antibody discovery process, including high-throughput purification and characterization of binders.​

The neoSwitch platform utilizes a yeast-based system that toggles between surface display for binder selection and protein secretion for downstream evaluation. This eliminates the need for labor-intensive subcloning and protein expression steps, significantly reducing overall process timelines.​

Key Features of the Opentrons Flex neoSwitch Workstation​

• Automated high-throughput purification of antibody binders

• Seamless transition between yeast surface display and protein secretion

• Pre-loaded, optimized protocols for walkaway automation

• Integration with Neochromosome's high-diversity antibody libraries

• Capability to perform protein quantification and genotype identification via colony PCR​

This workstation empowers laboratories to internalize and scale their antibody discovery pipelines efficiently, offering a cost-effective alternative to traditional outsourcing methods.